DEEP DIVE · CHAPTER 6
Advanced Glycation End Products
Tissue Turned to Glass
Advanced glycation end products form when glucose bonds permanently to the collagen in your tendons, discs and nerve tunnels, which is why trigger finger, carpal tunnel and frozen shoulder show up years before anyone says diabetes. This Deep Dive is the evidence behind Chapter 6, claim by claim.
30 pages · 77 references, every one verified · written by Dr. Gurpreet Singh Padda, MD, MBA, MHP, and Dr. KrisJay Fucanan, MD
CHAPTER 6 ON VIDEO
Sugar Is Turning Your Tissues to Glass
Dr. Padda walks through this chapter on video. All twenty-two are on the The Pained Brain playlist on the Padda Institute channel.
The receipts behind Chapter 6
A trigger finger, a carpal tunnel, a frozen shoulder, and nobody said the word sugar. In Chapter 6 I explain advanced glycation end products: how glucose bonds permanently to the collagen in your tendons, discs and nerve tunnels, why the stiffness shows up years before anyone says diabetes, and why a released nerve or repaired cuff is a bridge over a river that is still rising.
The book makes the argument. This Deep Dive shows the evidence, claim by claim: the study, who was in it, the number and where it sits in the paper, what it does not show — and the questions to bring to your own physician. It is written to be handed to your doctor.
Enter your name, email and mobile number. The PDF arrives by email within a few minutes, and the other twenty-one Deep Dives arrive one a week, in order.
Frequently asked questions
What are advanced glycation end products?
Advanced glycation end products form when glucose bonds permanently to the collagen in your tendons, discs and nerve tunnels. The bond does not come undone, and the tissue stiffens. Chapter 6 of The Pained Brain calls it tissue turned to glass, and the Deep Dive gives the evidence behind it in 30 pages with 77 verified references.
Can too much sugar cause tendon problems?
Chapter 6 says yes. Glucose bonds permanently to the collagen in tendons, discs and nerve tunnels, which is why trigger finger, carpal tunnel and frozen shoulder can show up years before anyone says the word diabetes. Often nobody says the word sugar at all while these problems are being treated.
Does surgery fix sugar-related stiffness?
Surgery can release a nerve or repair a cuff, but it does not stop glucose from bonding to collagen. In Chapter 6 Dr. Padda calls a released nerve or a repaired cuff a bridge over a river that is still rising: the local problem is fixed while the process that caused it keeps going.
Educational material. Not medical advice. If you are in the St. Louis area and want this looked at properly, that is what the Padda Institute is for.